Results 181 to 190 of about 35,808,162 (371)

Design and evaluation of collagen-inspired mineral-hydrogel nanocomposites for bone regeneration

, 2020
Akhil Patel, Samer H. Zaky, Karen Schoedel, Hongshuai Li, Vinayak Sant, Elia Beniash, Charles Sfeir, Donna B. Stolz, Shilpa Sant   +8 more
openalex   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Recent Progress of the Design and Engineering of Bismuth Oxyhalides for Photocatalytic Nitrogen Fixation

, 2021
Peishen Li, Shuai Gao, Qiming Liu, Peiren Ding, Yunyun Wu, Changzheng Wang, Shaobin Yu, Wen Liu, Qiang Wang, Shaowei Chen   +9 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Design and Synthesis of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs–CAIs) for the Treatment of Rheumatoid Arthritis

, 2017
Silvia Bua, Lorenzo Di Cesare Mannelli, Daniela Vullo, Carla Ghelardini, Gianluca Bartolucci, Andrea Scozzafava, Claudiu T. Supuran, Fabrizio Carta   +7 more
openalex   +1 more source

Principles of nanoparticle design for overcoming biological barriers to drug delivery

Nature Biotechnology, 2015
Elvin Blanco, Haifa Shen, M. Ferrari
semanticscholar   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Considering Part Orientation in Design for Additive Manufacturing

, 2016
Bastian Leutenecker-Twelsiek, Christoph Klahn, Mirko Meboldt   +2 more
openalex   +1 more source

Design and Application of a Distribution Network Phasor Data Concentrator [PDF]

, 2020
Weiqing Tao, Mengyu Ma, Chen Fang, Wei Xie, Ming Ding, Dachao Xu, Yangqing Shi   +6 more
openalex   +1 more source

Design Methodologies for Sizing of Drainage Stacks and Vent Lines in High-Rise Buildings [PDF]

, 2023
Michael Gormley, Colin Stewart
openalex   +1 more source