Results 211 to 220 of about 35,808,162 (371)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Care My Way: Co-Designing a Patient-Held Resource to Improve Information Sharing Between Primary and Specialist Care for People With Cancer. [PDF]

Health Expect
Harrison R, Newman B, Chauhan A, Holland K, Philibert C, Emerick J, Oataway K, Manias E, Wilson C.   +8 more
europepmc   +1 more source

Involving people with dementia in developing an interactive web tool for shared decision-making: experiences with a participatory design approach

, 2017
Marijke Span, Marike Hettinga, Leontine Groen-van de Ven, Jan Jukema, Ruud Janssen, Myrra Vernooij‐Dassen, Jan A. Eefsting, Carolien Smits   +7 more
openalex   +2 more sources

Design of MUX based Flash ADC for Reduction in Number of Comparators

, 2020
Tejaswini Jayawant Kutre, Sujata Patil, Sheela Kiran Kore   +2 more
openalex   +1 more source

Robust Finite-Time Control of a Multirotor System via an Improved Optimized Homogeneous Twisting Control: Design and Validation

, 2023
Aimen Abdelhak Messaoui, Omar Mechali, Ali Zakaria Messaoui, Iheb Eddine Smaali   +3 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Du design thinking au design fiction

Technologie et Innovation
Thomas Michaud
doaj   +1 more source

From Documents to Digital: Co-Designing Nutrition Information Videos With Consumers and Dietitians. [PDF]

Health Expect
Olufson H, Do H, Noble B, Power G, Moore J, Ong R, Harding S, Robertson S, Gunawardena T, Ellick J, Young A.   +10 more
europepmc   +1 more source

Juego de mesas 3x3, premio Delta de plata de los Premios Delta de 2012 [PDF]

, 2012
Product Design,
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source