Results 131 to 140 of about 636,549 (266)

Design and construction of internet-based cognitive-behavioural therapy for obsessive-compulsive disorder in Iran: A feasibility study. [PDF]

Internet Interv
Dorri-Mashhadi N, Mashhadi A, Maleki ZH, Bigdeli I.   +3 more
europepmc   +1 more source

Towards a barrier-free anthropomorphic brain phantom for quantitative magnetic resonance imaging: Design, first construction attempt, and challenges. [PDF]

PLoS One, 2023
Kraft M, Ryger S, Berman BP, Downs ME, Jordanova KV, Poorman ME, Oberdick SD, Ogier SE, Russek SE, Dagher J, Keenan KE.   +10 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Success criteria comparison of eight implemented projects to improve the planning, design, and construction of floodplain wetlands. [PDF]

PLOS Water
Hawley RJ, Nietch C, Knight D, Acosta S, Cooper K, Korth N, Raetz A, McManus J, McClatchy R, Hahn J, Lubbers H, Lair L, Winston RJ.   +12 more
europepmc   +1 more source

Structure-based design and construction of a synthetic phage display nanobody library. [PDF]

BMC Res Notes, 2022
Moreno E, Valdés-Tresanco MS, Molina-Zapata A, Sánchez-Ramos O.   +3 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Customizing egg incubators for Cameroon: A design and construction guide. [PDF]

PLoS One
Kemegne Tagne MJ, Kanaa T, Etouke Owoundi P, Obono Biyobo A.   +3 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

CloneFast: A simple plasmid design and construction guide for labs venturing into synthetic biology. [PDF]

STAR Protoc
Fung V, Tiwade PB, Fenton OS.
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source