Results 101 to 110 of about 14,128,484 (310)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Design Automation Using Exclusion-Based Hierarchical Computation for Power Electronics Converters in Harsh Environments

IEEE Open Journal of Power Electronics
Designing power electronics converters for harsh environments is challenging due to the absence of components' performance under harsh conditions, the frequent transition and data-passing among various software, and the time-consuming and ...
Yudi Xiao, Zhe Zhang, Gabriel Zsurzsan, Michael A.E. Andersen, Martin MacFadyen, Yuchuan Liao, Rafael Pena Alzola, Weijia Yuan, Min Zhang   +8 more
doaj   +1 more source

Automated Mechanism Design

, 2005
Mechanisms design has traditionally been a manual endeavor. In 2002, Conitzer and Sandholm introduced the automated mechanism design (AMD) approach, where the mechanism is computationally created for the specific problem instance at hand. This has several advantages: 1) it can yield better mechanisms than the ones known to date, 2) it applies beyond ...
openaire   +4 more sources

Fast finger design automation for industrial robots

Robotics Auton. Syst., 2019
Finger design automation is highly demanded from robot industries to fulfill the requirements of the agile market. Nevertheless, literature lacks a promising approach to automate the design process of reliable fingers for industrial robots.
M. Honarpardaz, J. Ölvander, M. Tarkian
semanticscholar   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Versatility and stability optimization of flow-focusing droplet generators via quality metric-driven design automation. [PDF]

Lab Chip, 2023
McIntyre D, Lashkaripour A, Arguijo D, Fordyce P, Densmore D.   +4 more
europepmc   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Context-Aware Technology Mapping in Genetic Design Automation. [PDF]

ACS Synth Biol, 2023
Engelmann N, Schwarz T, Kubaczka E, Hochberger C, Koeppl H.   +4 more
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

CAD–FEA Integrated Automation Platform for Structural Design, Deformation Simulation, and Size Optimization of Housings in External Gear Pumps

Applied Sciences
External spur gear pumps are widely employed in hydraulic systems for their simplicity, efficiency, and cost-effectiveness; however, the conventional CAD-based methods used to design these components remain time-intensive and prone to inconsistencies ...
Recep Cinar, H. Kursat Celik, Mehmet Ucar, Allan E. W. Rennie   +3 more
doaj   +1 more source