Results 81 to 90 of about 739,438 (302)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Tracking Control of A Balancing Robot – A Model-Based Approach

open access: yesArchive of Mechanical Engineering, 2014
This paper presents a control concept for a single-axle mobile robot moving on the horizontal plane. A mathematical model of the nonholonomic mechanical system is derived using Hamel's equations of motion.
Zaiczek Tobias, Franke Matthias
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

open access: yesFEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner   +7 more
wiley   +1 more source

Enhancing lower-limb rehabilitation: a scoping review of augmented reality environment

open access: yesJournal of NeuroEngineering and Rehabilitation
Background Lower-limb rehabilitation is crucial for restoring motor function in individuals with physical impairments; however, traditional rehabilitation approaches often encounter challenges such as limited resources and reduced patient motivation ...
Yuanyuan Liu, Qiong Zhang, Weiyi Li
doaj   +1 more source

Evaluating the Effectiveness of Autorouting in PCB Design

open access: yesEngineering Proceedings
This research aims to determine an optimized set of parameters for Altium Designer’s built-in autorouting function when applied on two- or more-layer printed circuit board (PCB) designs.
Péter Gulyás
doaj   +1 more source

Automated Mechanism Design

open access: yes, 2005
Mechanisms design has traditionally been a manual endeavor. In 2002, Conitzer and Sandholm introduced the automated mechanism design (AMD) approach, where the mechanism is computationally created for the specific problem instance at hand. This has several advantages: 1) it can yield better mechanisms than the ones known to date, 2) it applies beyond ...
openaire   +4 more sources

CMOS array design automation techniques [PDF]

open access: yes
The design considerations and the circuit development for a 4096-bit CMOS SOS ROM chip, the ATL078 are described. Organization of the ATL078 is 512 words by 8 bits.
Feller, A., Lombardi, T.
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

The use of artificial intelligence in adapting process of UI design system for end customer requirements

open access: yesРадіоелектронні і комп'ютерні системи
This paper demonstrates an approach for developing an AI-based UI design system to improve a company white labeling (aka rebranding) process. This is the process of removing a product or service's original branding and replacing it with the branding of ...
Kyrylo Polishchuk, Eugene Brezhniev
doaj   +1 more source

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