Results 61 to 70 of about 739,438 (302)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Modeling of Multi-Cell HBT Device Based on Device Structure

Micromachines
This paper focuses on the modeling challenges of a multi-cell heterojunction bipolar transistor (HBT) used in radio frequency (RF) power amplifiers and proposes an innovative linear small-signal modeling method. Based on devices with an emitter size of 3
Haoyi Zhao, Jun Liu, Tao Rong, Shiyue Fan, Zhanfei Chen, Junchao Wang   +5 more
doaj   +1 more source

Evolution of NULL Convention Logic Based Asynchronous Paradigm: An Overview and Outlook

IEEE Access, 2022
The synchronous design paradigm dominates today’s semiconductor industry. However, this clocked approach is facing major challenges with today’s high-speed, low-power design expectations, using processes with ever-increasing physical level ...
Danylo Khodosevych, Ashiq A. Sakib
doaj   +1 more source

MIDAS: Automated Approach to Design Microwave Integrated Inductors and Transformers on Silicon [PDF]

, 2013
The design of modern radiofrequency integrated circuits on silicon operating at microwave and millimeter-waves requires the integration of several spiral inductors and transformers that are not commonly available in the process design-kits of the ...
Alimenti, F., Aluigi, L., Pepe, D., Roselli, L., Zito, D.   +4 more
core   +1 more source

User expectations of partial driving automation capabilities and their effect on information design preferences in the vehicle [PDF]

, 2019
Partially automated vehicles present interface design challenges in ensuring the driver remains alert should the vehicle need to hand back control at short notice, but without exposing the driver to cognitive overload.
Birrell, Stewart A., Cain, Rebecca, Jennings, Paul. A., Mouzakitis, Alexandros, Skrypchuk, Lee, Thompson, Simon, Ulahannan, Arun   +6 more
core   +2 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Ensuring precision characteristics of equipment for rotary extrusion in the production of special technical products

Известия высших учебных заведений. Поволжский регион:Технические науки
Background. The level of development of mechanical engineering significantly affects the economic potential and defense capability of the state. One of the main areas of mechanical engineering is the manufacture of products for aerospace technology ...
A.Yu. Ryazantsev, S.S. Yukhnevich, A.P. Pechagin, V.A. Podshibyakina   +3 more
doaj   +1 more source

An Improved Parameter Extraction Optimization Algorithm for RF Devices

Micromachines
This paper proposes an improved parameter extraction optimization algorithm for radio frequency (RF) devices. The algorithm integrates parameter classification and correction, gradient-based performance handling, bias-aware updates, and group-based ...
Shengsen Yang, Zihan Xu, Kun Ren
doaj   +1 more source

COMBINED METHOD OF RANKING OPTIONS IN PROJECT DECISION SUPPORT SYSTEMS

Сучасний стан наукових досліджень та технологій в промисловості, 2020
The subject of research in the article is the process of ranking options in project decision support systems. The goal of the work is to create a method for ranking options to improve the efficiency of decision support systems by coordinating the ...
Vladimir Beskorovainyi
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source