Results 71 to 80 of about 14,128,484 (310)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

An Improved Parameter Extraction Optimization Algorithm for RF Devices

Micromachines
This paper proposes an improved parameter extraction optimization algorithm for radio frequency (RF) devices. The algorithm integrates parameter classification and correction, gradient-based performance handling, bias-aware updates, and group-based ...
Shengsen Yang, Zihan Xu, Kun Ren
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Design of a Hybrid Asymmetric LMBA With High Linearity Based on Improved Particle Swarm Optimization Method

IEEE Open Journal of Circuits and Systems
This paper presents an improved particle swarm optimization (PSO) method and applies it to the design of a hybrid asymmetric load modulated balanced amplifier (H-ALMBA) with high linearity. A description is provided of the H-ALMBA topology as well as the
Benhao Jin, Zhiming Fan, Giovanni Crupi, Jialin Cai   +3 more
doaj   +1 more source

A Contract-Based Methodology for Aircraft Electric Power System Design

IEEE Access, 2014
In an aircraft electric power system, one or more supervisory control units actuate a set of electromechanical switches to dynamically distribute power from generators to loads, while satisfying safety, reliability, and real-time performance requirements.
Pierluigi Nuzzo, Huan Xu, Necmiye Ozay, John B. Finn, Alberto L. Sangiovanni-Vincentelli, Richard M. Murray, Alexandre Donze, Sanjit A. Seshia   +7 more
doaj   +1 more source

Recent Advances on the Design Automation for Performance-Optimized Fiber Reinforced Polymer Composite Components

Journal of Composites Science, 2020
Advanced manufacturing techniques, such as automated fiber placement and additive manufacturing enables the fabrication of fiber-reinforced polymer composite components with customized material and structural configurations. In order to take advantage of
Y. D. Boon, S. Joshi, S. K. Bhudolia, Goram Gohel   +3 more
semanticscholar   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

COMBINED METHOD OF RANKING OPTIONS IN PROJECT DECISION SUPPORT SYSTEMS

Сучасний стан наукових досліджень та технологій в промисловості, 2020
The subject of research in the article is the process of ranking options in project decision support systems. The goal of the work is to create a method for ranking options to improve the efficiency of decision support systems by coordinating the ...
Vladimir Beskorovainyi
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source