Results 71 to 80 of about 956,226 (290)
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Elders’ experience with augmented gaze: preliminary observations
Gestalt Theory, 2023 Research on elders’ acceptance of virtual technologies is much needed. Here we studied the user experience of elders (N = 10, mean age = 88.2 years) during virtual biking, an exergame where participants pedal on a cycle ergometer and wear a Head-Mounted ...
Dalmasso Vittorio +6 more
doaj +1 more source
Bringing forth mathematical concepts: signifying sensorimotor enactment in fields of promoted action [PDF]
, 2014 Inspired by Enactivist philosophy yet in dialog with it, we ask what theory of embodied cognition might best serve in articulating implications of Enactivism for mathematics education. We offer a blend of Dynamical Systems Theory and Sociocultural Theory
Abrahamson, D, Trninic, D
core +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Fall Prediction and Prevention Systems: Recent Trends, Challenges, and Future Research Directions. [PDF]
, 2017 Fall prediction is a multifaceted problem that involves complex interactions between physiological, behavioral, and environmental factors. Existing fall detection and prediction systems mainly focus on physiological factors such as gait, vision, and ...
Jung, Tzyy-Ping +2 more
core +2 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Dynamic Difficulty Balancing for Cautious Players and Risk Takers
International Journal of Computer Games Technology, 2012 Dynamic balancing of game difficulty can help cater for different levels of ability in players. However, performance in some game tasks depends on not only the player's ability but also their desire to take risk. Taking or avoiding risk can offer players
Guy Hawkins, Keith Nesbitt, Scott Brown
doaj +1 more source
Once More, with Feeling: Design Thinking and Embodied Cognition
She Ji: The Journal of Design, Economics and Innovation, 2017 While leaders in business and industry maintain their interest in design thinking, academic discussions of the concept have become less common. This article examines design thinking in relation to developments in cognitive science and embodied cognition.
Karin Lindgaard, Heico Wesselius
doaj +1 more source
Abstract Understanding how designers think is central to HCI’s ability to produce useful knowledge. This chapter reviews designers’ thought processes, focusing on the methods they use for generating ideas, convergent/divergent thinking, and reconceptualization.
Kasper Hornbæk +2 more
openaire +1 more source
Assessment in mathematics: A multimedia resource for preservice teachers [PDF]
, 1996 It is commonly accepted that teachers teach the way they were taught and that innovation is difficult to achieve. In this project, the theoretical framework of situated cognition or situated learning has been used to design an interactive multimedia ...
Herrington, A. +2 more
core +1 more source