Results 181 to 190 of about 1,419,472 (305)

How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept. [PDF]

Front Bioeng Biotechnol, 2020
Marques C, Som C, Schmutz M, Borges O, Borchard G.   +4 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Villa Arconati revitalization. A restaurant design by natural concept

, 2018
LAUREA MAGISTRALELa Villa Arconati fu costruita nei secoli XVII e XVIII, ora funge da museo e ospita eventi e incontri. Per attuare il valore della conservazione della Villa Arconati e della divulgazione, il riuso di Villa Arconati dovrebbe preoccuparsi ...
WAN, CHIH-WEI
core  

Design concept and phase transformation study of advanced bainitic-austenitic medium-Mn steel. [PDF]

Sci Rep
Wojtacha A, Kozłowska A, Skowronek A, Gulbay O, Opara J, Gramlich A, Matus K.   +6 more
europepmc   +1 more source

Independent Tailoring of Dose and Drug Release via a Modularized Product Design Concept for Mass Customization. [PDF]

Pharmaceutics, 2020
Govender R, Abrahmsén-Alami S, Larsson A, Borde A, Liljeblad A, Folestad S.   +5 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Accuracy of 3-dimensional surgical guide for endodontic microsurgery with a new design concept: A cadaver study. [PDF]

Int Endod J
Ha SW, Choi SM, Kim S, Song M, Hu KS, Kim E.   +5 more
europepmc   +1 more source

Polyethylene-Based Knee Spacer for Infection Control: Design Concept and Pre-Clinical In Vitro Validations. [PDF]

Polymers (Basel), 2020
Chang Y, Lee MS, Liau JJ, Liu YL, Chen WC, Ueng SWN.   +5 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Application of ICU electronic diary platform based on co-design concept in Chinese critically ill patients: a mixed methods study protocol. [PDF]

BMJ Open
Li L, Pan X, Tong Q, Gao H, Yuan Y, Zhang X, Chen J, Chang Y, Zhang T, Hu R.   +9 more
europepmc   +1 more source