Results 71 to 80 of about 4,466,204 (357)

TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation

FEBS Letters, EarlyView.
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling, Kodi Hunter, Celest W. S. Tay, Nicola T. Wood, Philip Cohen   +4 more
wiley   +1 more source

Evaluation of Standard Concepts Design of Library Interior Physical Environment (Case Study at University of Ma Chung)

Record and Library Journal, 2016
Currently the function of a room is not only used as a shelter, the function of the room itself to be increased as a refreshing or relaxation area for users to follow the development of creativity and technology in the field of design.
Debri Haryndia Putri
doaj   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

A novel design concept for space-based polar remote sensing [PDF]

, 2012
Space-based remote sensing of the Earth is conducted from a fleet of spacecraft in two basic orbital positions, near-polar low-Earth orbits and geosynchronous orbits, with each offering its own advantages and disadvantages.
Anderson, Pamela, Macdonald, Malcolm, Warren, Carl   +2 more
core  

Survey and documentation of emerging technologies for the Satellite Power System (SPS) [PDF]

, 1981
The genesis of the solar power satellite (SPS) concept is reviewed historically and the original assumptions and guidelines which led to development of the SPS reference system design concept are discussed.
Chapman, P., Glaser, P.
core   +2 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Concept Blending and Dissimilarity: Factors for Creative Design Process: A Comparison between the Linguistic Interpretation Process and Design Process [PDF]

, 2009
This study investigated the design process in order to clarify the characteristics of the essence of the creative design process vis-à-vis the interpretation process, by carrying out design experiments.
Mukai, Futoshi, Nagai, Yukari, Taura, Toshiharu   +2 more
core  

EXIST: Mission Design Concept and Technology Program [PDF]

, 2002
The Energetic X-ray Imaging Survey Telescope (EXIST) is a proposed very large area coded aperture telescope array, incorporating 8m^2 of pixellated Cd-Zn-Te (CZT) detectors, to conduct a full-sky imaging and temporal hard x-ray (10-600 keV) survey each ...
Craig, W. W., Gehrels, N., Grindlay, J. E., Harrison, F. A., Hong, J.   +4 more
core   +2 more sources

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Development of visible light‐sensitive human neuropsin (OPN5) via single amino acid substitution

FEBS Letters, EarlyView.
The present study determines a key amino acid residue, Lys91, for defining UV sensitivity of human OPN5. Heterologous action spectroscopy of the wild type and K91 mutants of OPN5 in HEK293T cells reveals that substitution of Lys91 with neutral (alanine) or acidic amino acids (glutamic or aspartic acids) causes substantial shifts in spectral sensitivity
Yusuke Sakai, Richard J. McDowell, Robert J. Lucas   +2 more
wiley   +1 more source