Results 91 to 100 of about 4,803,101 (299)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Fuel element concept for long life high power nuclear reactors [PDF]
, 1969 Nuclear reactor fuel elements have burnups that are an order of magnitude higher than can currently be achieved by conventional design practice. Elements have greater time integrated power producing capacity per unit volume.
Mcdonald, G. E., Rom, F. E.
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Active concept in pedestrian design
ARTEKS : Jurnal Teknik Arsitektur, 2017 Saat ini terdapat tren perancangan kota dengan konsep active living yang membuat penduduk kota menjadi lebih aktif bergerak, secara keseluruhan menjadikan kota lebih sehat (healthy city).
Christianto Hendrawan +1 more
doaj +1 more source
Design concept for the Flight Telerobotic Servicer (FITS) [PDF]
NASA has just completed an in-house Phase B Study (one of three studies) for the preliminary definition of a teleoperated robotic device that will be used on the National Space Transportation System (NSTS) and the Space Station to assist the astronauts ...
Andary, J. F. +2 more
core +1 more source
Paper 99: design guidelines versus practices for the Upper Seascheldt, the inland waterway connection between Antwerp and Ghent [PDF]
, 2015 Design guidelines for inland waterways are so far a national matter. PIANC InCom Working Group 141 "Design Guidelines for Inland Waterways" is nevertheless working on a report with a summary of existing guidelines and a methodology for the concept and ...
Adams, R +4 more
core
Retracted: Intelligent Face Recognition System Based on Universal Design Concept. [PDF]
Comput Intell Neurosci, 2023 Intelligence And Neuroscience C.
europepmc +1 more source