Results 111 to 120 of about 1,419,472 (305)

An MAGDM method for design concept evaluation based on incomplete information. [PDF]

PLoS One, 2022
Chen Z, Pan Z, Ma Q, Hou T, Zhao P.
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Happy moments: A well-being driven design of a Car2Go

, 2016
User well‐being is increasingly addressed in design and design research. Previous work has proposed a design for well-¬‐being framework that includes three main ingredients: pleasure, personal significance, and virtue. While useful for analysing the well-
Duste, Tessa, van Grondelle, Elmer, Duste, T. (author), Tessa Duste, Elmer van Grondelle, Pieter Desmet, Desmet, Pieter, Desmet, P.M.A. (author), van Grondelle, E.D. (author)   +8 more
core   +1 more source

A design concept of big data analytics model for managers in hospitality industries. [PDF]

Pers Ubiquitous Comput, 2023
Mousavian S, Miah SJ, Zhong Y.
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

From sign to design: The role of domain transfer in redefining architecture locality

ARTEKS : Jurnal Teknik Arsitektur
This research examines the design process using conceptual frameworks based on domain transfer to suggest a new model for architecture based on local contexts.
Bramasta Putra Redyantanu, Rony Gunawan Sunaryo   +1 more
doaj   +1 more source

An integrated expert weight determination method for design concept evaluation. [PDF]

Sci Rep, 2022
Chen Z, Zhong P, Liu M, Ma Q, Si G.
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Creative vs Defective: A Critical Review of Malang Creative Center (MCC) in Malang City

RUAS
The Malang Creative Center (MCC) construction is a step taken by the Malang City government to support the flow of modernization and as a forum for Malang residents to develop their creativity. The MCC display concept is planned by combining the shape of
Bunga Pasadena Ineru, Yusfan Adeputera Yusran, Joko Triwinarto Santoso, Moch. Ardiansyah Fendy Wijaya, Susilo Kusdiwanggo   +4 more
doaj   +1 more source