Results 131 to 140 of about 4,803,101 (299)

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Reliability Risk Evaluation during the Conceptual Design Phase

open access: yesActa Polytechnica, 2006
I (Relative Reliability Risk Index) is calculated and the idea of concept functionality graphs is presented.  This method is applied on the example of seat suspensions for an off highway vehicle and the results are discussed.
G. Mamtani, G. Green
doaj  

Explosive-actuated valve design concept that eliminates blow-by [PDF]

open access: yes
A method of evaluating the normally open normally closed, explosive actuated valves that were selected for use in the trajectory correction propulsion subsystem of the Thermoelectric Outer Planet Spacecraft (TOPS) program is presented.
Hagler, R., Jr.
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

SymPET, a waveform digitizing "System on Chip" for ultra-high resolution TOF PET: design concept and preliminary studies. [PDF]

open access: yesIEEE Nucl Sci Symp Conf Rec (1997), 2022
Flood K   +9 more
europepmc   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

An Integrated Decision Making Model for Evaluation of Concept Design

open access: yesActa Polytechnica, 2004
The Conceptual design phase generates various design concepts and these are then evaluated in order to identify the 'Best’ concept. Identifying the Best concept is important because much of the product life cycle cost is decided in this phase.
G. Green, G. Mamtani
doaj  

Is spatial intelligibility critical to the design of largescale virtual environments? [PDF]

open access: yes, 2002
This paper discusses the concept of 'intelligibility', a concept usually attributed to the design of real-world environments and suggests how it might be applied to the construction of virtual environments.
Conroy-Dalton, R
core  

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