Results 141 to 150 of about 4,803,101 (299)
Down to the Bone: A Novel Bio-Inspired Design Concept. [PDF]
Materials (Basel), 2021 Buccino F +7 more
europepmc +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Artifact, 2015 Abstract In this volume of Artifact, we wish to explore design through the design concept, and thereby the societal praxis of designers through the theoretical concept of design. Design is praxis, but it is also formed by the way we frame the concept of design.
openaire +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
A novel design concept for space-based polar remote sensing [PDF]
, 2012 Space-based remote sensing of the Earth is conducted from a fleet of spacecraft in two basic orbital positions, near-polar low-Earth orbits and geosynchronous orbits, with each offering its own advantages and disadvantages.
Anderson, Pamela +2 more
core
Wi-Fi Access Point Design Concept Targeting Indoor Positioning for Smartphones and IoT. [PDF]
Sensors (Basel), 2022 El-Gendy MS, Ashraf I, El-Hennawey S.
europepmc +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Culture and concept design : a study of international teams [PDF]
, 2011 This paper explores the relationship between culture and performance in concept design. Economic globalisation has meant that the management of global teams has become of strategic importance in product development.
Grierson, Hilary +3 more
core
A Novel Design Concept of Cemented Paste Backfill (CPB) Materials: Biobjective Optimization Approach by Applying an Evolved Random Forest Model. [PDF]
Materials (Basel), 2022 He Y +7 more
europepmc +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source