Results 101 to 110 of about 1,419,472 (305)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
A Proposal for a Formal Definition of the Design Concept
, 2013 A clear and unambiguous definition of the design concept would be use- ful for developing a cumulative tradition for research on design. In this article we suggest a formal definition of the concept design and propose a conceptual model linking concepts ...
Wand, Yair, Ralph, Paul
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Application of the Quality by Design Concept (QbD) in the Development of Hydrogel-Based Drug Delivery Systems. [PDF]
Polymers (Basel), 2023 Mohseni-Motlagh SF +3 more
europepmc +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Design and technology education and the concept of property
, 2008 Knobler (1971) notes that within society at least three communities are affected by intellectual property rights and these include; the stakeholders who produce and distribute the new knowledge such as Microsoft or Disney, individual generators of new ...
Molwane, Olefile Bethuel +1 more
core +1 more source
A novel MCDM approach for design concept evaluation based on interval-valued picture fuzzy sets. [PDF]
PLoS One, 2023 Ma Q, Sun H, Chen Z, Tan Y.
europepmc +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
A novel integrated MADM method for design concept evaluation. [PDF]
Sci Rep, 2022 Chen Z, Zhong P, Liu M, Ma Q, Si G.
europepmc +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Integrated design and PLM applications in aeronautics product development [PDF]
, 2009 Organised by: Cranfield UniversityWell known challenges in Aeronautic industry, namely reducing time to market, risks and development costs, could be reached thanks to innovative design methods supported by PLM technologies.
EYNARD, Benoit +11 more
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