Results 51 to 60 of about 195,920 (264)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Procedimento para seleção de interfaces para produtos modulares baseado no ciclo de projeto de produtos Procedure for interface selection for modular products based on the product design cycle

Production, 2012
Este artigo aborda a definição de alternativas de interfaces durante desenvolvimento de produtos modulares. Entende-se por interfaces a fronteira entre os módulos que compõem o produto, bem como as interações existentes entre o meio-ambiente em que o ...
Régis Kovacs Scalice, Luiz Fernando Segalin de Andrade, Fernando Antonio Forcellini   +2 more
doaj  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Development of pseudo interface element for modelling of reinforced brick masonry

Revista ALCONPAT, 2017
Development of pseudo interface element for modelling of reinforced brick masonry ABSTRACT Strength of reinforced masonry is influenced by interfaces between brick, mortar and reinforcement.
Shashank Vasudeo Mehendale, Abhay Namdev Bambole, S Raghunath   +2 more
doaj   +1 more source

Recomendações de design universal para uso de Mobile User Interface Design Patterns

Anais Estendidos do Simpósio Brasileiro de Fatores Humanos em Sistemas Computacionais (IHC), 2019
O uso de Padrões de Design da Interface do Usuário (User Interface Design Patterns) (UIDP) é visto como uma boa prática para o desenvolvimento de softwares interativos. No entanto, ao aplicar esses padrões, o designer da interface pode introduzir problemas de acessibilidade no software.
Luciana Zaina, Leonardo Nozaki
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Le No Interface et la surveillance liquide

Interfaces Numériques, 2018
Dans son dernier livre, Golden Krishna constate que la multiplication et le recours sans cesse plus important aux écrans ont des effets néfastes pour les utilisateurs. L’auteur en appelle à imaginer des expériences sans écran, le No Interface.
Fabien Richert
doaj   +1 more source

Design hacker e as customizações de interface gráfica

DAT Journal, 2020
Compilado e revisita de descobertas da pesquisa de mesmo nome, este artigo se divide em três pilares: no primeiro, é realizado um exercício livremente inspirado na arqueologia de interface, com foco na customização na história da computação. Investigamos como as opções de customização se consolidam em sistemas operacionais desktop para Macintosh.
openaire   +2 more sources