Results 61 to 70 of about 195,920 (264)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Acta Scientiarum: Technology, 2009 Este artigo apresenta uma interface gráfica para a ferramenta SimpleScalar, que auxilia o desenvolvimento de projeto, simulação e avaliação de desempenho de arquiteturas superescalares.
Rodrigo Richard Cantos Faveri +2 more
doaj
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Estudo sobre análise heurística aplicada no design de interfaces
, 2023 O objetivo deste trabalho foi analisar As heurísticas de Nielsen que servem para inúmeros tipos de aplicação na interface de Games e Sites. Ao aplicar estas heurísticas no planejamento da interface é possível extrair os benefícios da aplicação em diferentes jogos e Sites.
Santos, José Clairton Moura dos +1 more
openaire +2 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Production, 2009 Este artigo apresenta a Análise Ergonômica Experiencial do Ambiente Construído (AEE), em continuidade à discussão da Avaliação Ergonômica do Ambiente Construído proposta por Villarouco.
Juliane Figueiredo Fonseca +1 more
doaj +1 more source
DESIGN INCLUSIVO DE INTERFACE DE APLICATIVOS DIRIGIDOS A ANALFABETOS FUNCIONAIS.
IROCAMM-International Review Of Communication And Marketing Mix, 2019 In this article, we highlight aspects of an investigation that seeks to build an inclusive design, which can support the development of an application prototype aimed at improving the writing and reading levels of functional illiterates - from the rudimentary level.
Darlan Rodrigues Martins +3 more
openaire +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source