Results 11 to 20 of about 9,580,623 (304)

A Bayesian adaptive marker‐stratified design for molecularly targeted agents with customized hierarchical modeling [PDF]

open access: yes, 2019
It is well known that the treatment effect of a molecularly targeted agent (MTA) may vary dramatically, depending on each patient's biomarker profile. Therefore, for a clinical trial evaluating MTA, it is more reasonable to evaluate its treatment effect ...
Cao, Sha   +4 more
core   +3 more sources

On Hirth Ring Couplings: Design Principles Including the Effect of Friction [PDF]

open access: yes, 2018
Rings with Hirth couplings are primarily used for the accurate positioning of axial-symmetric components in the machine tool industry and, generally, in mechanical components. It is also possible to use Hirth rings as connection tools.
Croccolo, Dario   +5 more
core   +2 more sources

Testing methodologies for corrosion fatigue [PDF]

open access: yes, 2015
Offshore constructions are subjected to cyclic loading conditions. This situation is combined with the corrosive nature of the surrounding environment. It is of actual concern whether the combined effect is more damaging or not than the superposition of ...
De Waele, Wim   +2 more
core   +1 more source

Real-effort survey designs: Open-ended questions to overcome the challenge of measuring behavior in surveys

open access: yesJournal of Trial and Error, 2021
Based on data triangulation, open-ended questions can be used to overcome a typical problem with data collection using surveys: Human behavior can only be captured as stated or intended, but not as real behavior. In this study on knowledge sharing in the
Caroline Fischer
doaj   +1 more source

Rural children active trachoma risk factors and their interactions

open access: yesThe Pan African Medical Journal, 2016
INTRODUCTION: trachoma is a serious public health problem in rural Ethiopia. The aim of this investigation was to provide in-depth statistical analysis of the risk factors associated with active trachoma among children of age 1-9 years of Kedida Gamela ...
Essey Kebede Muluneh   +2 more
doaj   +1 more source

Determination of Temperature Conditions for a Design of Engineering Constructions during a Fire

open access: yesCommunications, 2011
The problem of an engineering constructions design for effects of fire results from contemporary knowledge and procedures used in technical practice, however, is not limited only to norm recommendations, but looks also for other suitable methods of ...
Petr Kucera, Jiri Pokorny
doaj   +1 more source

Designing Effective Hybrid Toxins [PDF]

open access: yesChemistry & Biology, 2005
A study of a well-designed androgen-mustard conjugate provides evidence supporting a novel mechanism for its selective toxicity in androgen-receptor-positive cancer cells. This represents a solid step forward on the path toward effective hybrid toxins for targeted cancer therapy.
openaire   +2 more sources

Generalised variance functions for longitudinal survey data

open access: yesStatistical Theory and Related Fields, 2019
In this research, we propose longitudinal generalised variance functions (LGVFs) to produce convenient estimates of variances by incorporating time effect into modelling.
Guoyi Zhang, Yang Cheng, Yan Lu
doaj   +1 more source

Effect of steam addition on gas turbine combustor design and performance [PDF]

open access: yes, 2016
Adding steam influences the combustion process inside the combustor, which should be taken into account during combustor design. The design of combustor has long been the most challenging process.
Hu, Chunbo   +4 more
core   +1 more source

A Multilevel Analysis of the Effect of Prompting Self-Regulation in Technology-Delivered Instruction [PDF]

open access: yes, 2008
We used a within-subjects design and multilevel modeling in two studies to examine the effect of prompting self-regulation, an intervention designed to improve learning from technology-delivered instruction.
Bell, Bradford S   +3 more
core   +5 more sources

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