Results 101 to 110 of about 13,199,226 (301)
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
, 2013 In this publication, members of SEE share experiences of enhancing design in public sector ...
Design Council, UK
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Look-ahead gear-shifting strategy on ramps for heavy trucks with automated mechanical transmission
Advances in Mechanical Engineering, 2019 Look-ahead information has been applied to vehicle shift systems and has led to the development of innovative changes in shifting strategies. A shifting strategy significantly influences the dynamic and economic performance of a truck. If a shift control
Xiao-yan Cong +4 more
doaj +1 more source
The design of efficient algorithms for enumeration
CoRR, 2016 Many algorithms have been developed for enumerating various combinatorial objects in time exponentially less than the number of objects. Two common classes of algorithms are dynamic programming and the transfer matrix method. This paper covers the design and implementation of such algorithms.
openaire +3 more sources
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Geomatics, Natural Hazards & RiskCharacterisation of the spatial heterogeneity of urban flood resilience (UFR) under extreme rainfall events can support decision-making in urban planning and emergency management.
Junqi Mao +5 more
doaj +1 more source
Optimal and Efficient Designs of Experiments
The Annals of Mathematical Statistics, 1969 This paper consists of new results continuing the series of papers on optimal design theory by Kiefer (1959), (1960), (1961), Kiefer and Wolfowitz (1959), (1960), Farrell, Kiefer and Walbran (1965) and Karlin and Studden (1966a). After disposing of the necessary preliminaries in Section 1, we show in Section 2 that in several classes of problems an ...
openaire +3 more sources
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Energy Efficiency Board 2017 programs and operations report.
, 2018 Annual; Began with 2010; ceased with 2011.; At head of title: Connecticut Energy Efficiency ...
Connecticut. Energy Efficiency Board.
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, 2016 An empirically grounded understanding about which knowledge and skills that are sought from designers is missing for a number of professional subfields of design. This gap in research challenges i) design educators in planning their educational offerings
Person, Oscar +4 more
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