Results 131 to 140 of about 4,675,322 (307)
The discipline of Natural Design [PDF]
, 2008 If we define design work as those cognitive and practical things to which designers give their valuable effort, then our Natural Design framework allows the recording and replaying of design work. Natural Design provides a meta-structural framework that
Hall, Jon G, Rapanotti, Lucia
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Perencanaan Detail Engineering Design (Ded) Pengembangan Tempat Pemrosesan Akhir (Tpa) Sukoharjo Kabupaten Pati [PDF]
, 2017 Dinas Pekerjaan Umum Kabupaten Pati merupakan instansi pemerintah yang salah satu bidang kerjanya adalah menangani persampahan, mulai dari proses pewadahan hingga pemrosesan akhir di TPA. TPA Sukoharjo merupakan satu dari tiga Tempat Pemrosesan Akhir di
Hadiwidodo, M. (Mochtar) +2 more
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Mechanical dissection in an introductory engineering design module [PDF]
, 2010 The introductory design module for first year students in the Department of Mechanical Engineering at the University of Strathclyde uses mechanical dissection as a focus for learning activities that seek to integrate engineering science with the prior ...
Jenkins, Peter, McLaren, A.J.
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Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Creativity in Mass-Education Contexts [PDF]
, 2006 This paper discusses a learning framework (working title: ‘fog framework’) that has been developed in response to the challenge of teaching creative subjects in a mass-education context.
Anusas, M.
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Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Design, Engineering and Discovery of Novel α-Helical and β-Boomerang Antimicrobial Peptides against Drug Resistant Bacteria. [PDF]
Int J Mol Sci, 2020 Bhattacharjya S, Straus SK.
europepmc +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source