Results 111 to 120 of about 14,728,610 (293)

Design and design centers in engineering education

Artificial Intelligence for Engineering Design, Analysis and Manufacturing, 1998
This paper is intended to be the opening salvo of the workshop, Computing Futures in Engineering Design (Dym, 1997). Thus, I want to take this privileged moment to ask you to think with me about the role of design in engineering. In particular, I want to reflect upon how design is articulated and how design is taught; about the role of design in ...
openaire   +3 more sources

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

A Future Vision For The Engineering Design Environment: A Future Sociotechnical Scenario

, 2003
This paper presents a future vision for the working practices of designers within a manufacturing organisation. By its very nature the engineering design environment is highly distributed in nature and is characterised by a large number of information ...
Richard Crowder, Mike Moss, Hall, W, Wendy Hall, Hall, Wendy, Chris Clegg, Clegg, Chris, Moss, M, Bracewell, RH, Waterson, Patrick, Hughes, G, Wallace, KM, Wallace, Ken, Knott, David, David Knott, Kerr, M, Hughes, Gareth, Ken Wallace, Patrick Waterson, Gareth Hughes, Knott, D, Crowder, R, Crowder, Richard, ,, Rob Bracewell, Kerr, Micky, Clegg, C, Waterson, P, Micky Kerr, Bracewell, Rob, Moss, Mike   +30 more
core  

A Two-Stage Model of Adaptable Product Platform for Engineering-to-Order Configuration Design

, 2015
Product platforms are used to enable mass-customization to serve a large number of different market segments. The products are configured-to-order, meaning they are compiled using a variety of pre-developed building blocks.
Jiao, Jianxin (Roger), Jiao, Jianxin (Roger),, Levandowski, Christoffer E, Levandowski, Christoffer E,, Johannesson, Hans L,, Johannesson, Hans L   +5 more
core   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Potential for innovative massive building envelope systems – Scenario development towards integrated active systems

Journal of Facade Design and Engineering, 2015
In order to generate possible scenarios about future developments of massive constructions, this paper explains the developmental paths on the basis of individual materials of clay/brick as well as concrete/lightweight concrete/aerated concrete and sand ...
Ulrich Knaack
doaj  

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source