Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
A preliminary study of the nonlinearity of adhesive point-fixings in structural glass facades
Journal of Facade Design and Engineering, 2014 Corresponding author: Jonas Dispersyn, Laboratory for Research on Structural Models (LMO), Department of Structural Engineering, Faculty of Engineering and Architecture, Ghent University, Ghent, Belgium.
Jonas Dispersyn +3 more
doaj
Analysis and experimental validation of a pressure control method using magneto-rheology fluid flows
The Journal of Engineering, 2018 In this study, a spool actuating mechanism using controlled pressure difference is proposed for a large hydraulic servo valve. The actuating mechanism is accomplished by tuning magneto-rheological (MR) fluid flow.
Fan Wang, Ning Guo, Linxiang Wang
doaj +1 more source
"Why couldn't we do this more often?": exploring the feasibility of virtual and distributed work in product design engineering. [PDF]
Res Eng Des, 2022 Ferguson S +5 more
europepmc +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Design Engineering, Synthesis Protocols, and Energy Applications of MOF-Derived Electrocatalysts. [PDF]
Nanomicro Lett, 2021 Radwan A, Jin H, He D, Mu S.
europepmc +1 more source
Design evolution through customer interaction with functional prototypes
, 2007 Published ArticleThere can be a tendency, even within companies who practice concurrent engineering, to limit customer involvement to the initial and final stages of the new product development process only.
De Beer, D. J. +3 more
core
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Innovative design tool for the optimization of blast-enhanced facade systems
Journal of Facade Design and Engineering, 2015 In current blast enhancement design strategies, to resist the effects of an accidental explosion, a facade system is commonly designed to behave in-elastically and undergo large deformations. The large deformation of the facade system leads to high blast
Marc Zobec +4 more
doaj
Feasibility study of an induction motor rim drive for an aircraft boundary-layer-ingestion fan
The Journal of Engineering, 2019 This study presents a feasibility study for an induction motor rim drive to power aircraft boundary-layer-ingestion (BLI) fans. The design is developed from a BLI-fan specification for traditional aircraft architecture: the rotor is fastened to the rim ...
Alexander C. Smith +2 more
doaj +1 more source