Results 101 to 110 of about 5,340,578 (302)

Cell penetrating peptide (CPP) gold(iii) - complex - bioconjugates: from chemical design to interaction with cancer cells for nanomedicine applications. [PDF]

Nanoscale Adv, 2022
Arib C, Griveau A, Eyer J, Spadavecchia J.   +3 more
europepmc   +1 more source

PGPG: An Automatic Generator of Pipeline Design for Programmable GRAPE Systems [PDF]

, 2007
We have developed PGPG (Pipeline Generator for Programmable GRAPE), a software which generates the low-level design of the pipeline processor and communication software for FPGA-based computing engines (FBCEs).
Fukushige, Toshiyuki, Hamada, Tsuyoshi, Makino, Junichiro   +2 more
core   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Maximum a posteriori estimation for high-throughput peak fitting in X-ray photoelectron spectroscopy

Science and Technology of Advanced Materials: Methods
We introduce a peak fitting method to estimate the model parameters and the number of peaks without using the conventional trial-and-error approach. The proposed method automatically removes excess peaks using maximum a posteriori estimation.
Tarojiro Matsumura, Naoka Nagamura, Shotaro Akaho, Kenji Nagata, Yasunobu Ando   +4 more
doaj   +1 more source

User perspective for interactive handbag design

Proceedings of the 18th International Conference on Human-Computer Interaction with Mobile Devices and Services Adjunct, 2016
In this paper, we address handbags as interactive mobile devices. As handbags are typical accessories carried practically by half of the adult population when on the move, they offer an interesting and widely distributed platform for mobile computing.
Pakanen Minna Anneli, Colley Ashley, Häkkilä Jonna, Lappalainen Tuomas   +3 more
openaire   +1 more source

High luminosity interaction region design for collisions with detector solenoid

, 2010
An innovatory interaction region has been recently conceived and realized on the Frascati DA{\Phi}NE lepton collider. The concept of tight focusing and small crossing angle adopted until now to achieve high luminosity in multibunch collisions has evolved
Milardi, C., Preger, M., Raimondi, P., Sensolini, G., Sgamma, F.   +4 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Bodystorming for movement-based interaction design

Human Technology, 2016
After a decade of movement-based interaction in human-computer interaction, designing for the moving body still remains a challenge. Research in this field requires methods to help access, articulate, and harness embodied experiences in ways that can inform the design process.
Márquez Segura, Elena, Turmo Vidal, Laia, Rostami, Asreen   +2 more
openaire   +5 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source