Results 71 to 80 of about 5,340,578 (302)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Engagement in Human-Agent Interaction: An Overview
Frontiers in Robotics and AI, 2020 Engagement is a concept of the utmost importance in human-computer interaction, not only for informing the design and implementation of interfaces, but also for enabling more sophisticated interfaces capable of adapting to users.
Catharine Oertel +6 more
doaj +1 more source
Biomorpher: Interactive evolution for parametric design [PDF]
International Journal of Architectural Computing, 2018 Combining graph-based parametric design with metaheuristic solvers has to date focused solely on performance-based criteria and solving clearly defined objectives. In this article, we outline a new method for combining a parametric modelling environment with an interactive Cluster-Orientated Genetic Algorithm.
John Harding, Cecilie Brandt-Olsen
openaire +2 more sources
The Confluence of Interaction Design & Design: from Disciplinary to Transdisciplinary Perspectives [PDF]
, 2009 In keeping with the conference theme of rigour and the authors’ interest in sustainability and interaction design, we describe the confluence of design-oriented notions of interaction design and HCI-oriented notions of interaction design in terms of ...
Blevis, Eli, Stolterman, Erik
core
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Interaction design for paediatric emergency VR training
Virtual Reality & Intelligent Hardware, 2020 Background: Virtual reality (VR) in healthcare training has increased adoption and support, but efforts are still required to mitigate usability concerns.
Tj Matthews, Feng Tian, Tom Dolby
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Is movement better? Comparing sedentary and motion-based game controls for older adults [PDF]
, 2013 Providing cognitive and physical stimulation for older adults is critical for their well-being. Video games offer the opportunity of engaging seniors, and research has shown a variety of positive effects of motion-based video games for older adults ...
Dergousoff, Kristen K. +2 more
core +2 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source