Results 21 to 30 of about 19,879 (265)

RANCANGAN PERBAIKAN PRODUK SAKLAR DENGAN INTEGRASI METODE QFD DAN DFMA DI PT XXX

open access: yesJ@ti Undip: Jurnal Teknik Industri, 2013
Tahap desain memegang peranan penting dalam proses produksi produk saklar, hal ini dikarenakan desain berhubungan dengan proses manufaktur, waktu perakitan dan biaya produksi produk.
Rosnani Ginting   +2 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Design for Deconstruction of resilient bridge columns to dynamic loads

open access: yesDevelopments in the Built Environment
The resilience and sustainability of transport assets increasingly depend on their ability to rapidly adapt, repair, and reuse critical bridge components.
Nadiia Kopiika   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Pengembangan Alat Bantu Arbor untuk Pembuatan Roda Gigi pada Mesin Frais Vertikal

open access: yesRekayasa Mesin, 2021
The machining process is included in the classification of metal cutting processes, which are used to change the shape of metal or non-metallic product by cutting, peeling or separating. One of the machines used in this cutting process is a vertical type
Widodo Widodo, Rahman Hakim
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Integrating Design for Manufacturing and Assembly Principles in Modular Home Construction: A Comprehensive Framework for Enhanced Efficiency and Sustainability

open access: yesBuildings
The growing demand for sustainable and efficient construction practices has led to an increased interest in modular construction, with design for manufacture and assembly emerging as a pivotal approach.
Sadaf Montazeri   +3 more
doaj   +1 more source

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