Results 31 to 40 of about 19,879 (265)

Modeling evaluation for fire resistance design of rail car floor assembly

Case Studies in Thermal Engineering, 2022
This paper is prepared to report the engineering practice by a Chinese railcar manufacture in a railcar design process for a Metro system in U.S. The fire resistance of rail car floor systems is considered as one of the important fire protection features
Yantong Liu, Charles Luo, Wanxiu Teng, Anil Kapahi, Yang Gao, Xin Tian, Ervin Cui   +6 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Modular Construction in the Digital Age: A Systematic Review on Smart and Sustainable Innovations

Buildings
Modular construction provides numerous benefits over traditional methods, especially when combined with digital technologies, offering a faster, safer, leaner, and more sustainable construction environment.
Diogo F. R. Parracho, Mohamed Nour El-Din, Iraj Esmaeili, Sara S. Freitas, Leonardo Rodrigues, João Poças Martins, Helena Corvacho, João M. P. Q. Delgado, Ana Sofia Guimarães   +8 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

MIVES multi-criteria framework to sustainability index of design for manufacture and assembly

Journal of Civil Engineering and Management
Embracing sustainable strategies that consider Design for Manufacture and Assembly (DfMA) has become a rapidly growing trend in urban development.
Tan Tan, Lang Zheng, Fan Xue, Zhikang Bao, Zigeng Fang, Xiaohu Liu   +5 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

DfMA Integrated Assessment Model for Selecting Optimal Design Alternatives in OSC Projects

Buildings
To select the optimal design alternative in off-site construction (OSC) projects, the building industry has turned to design for manufacturing and assembly (DfMA).
Seoyoung Jung, Seulki Lee, Jungho Yu
doaj   +1 more source

Design for manufacture and assembly in construction: a review [PDF]

Building Research & Information, 2019
Design for Manufacture and Assembly (DfMA) is known as both a philosophy and a methodology whereby products are designed in a way that is as amenable as possible for downstream manufacturing and assembly. As construction is moving towards a combination of offsite prefabrication and onsite assembly, DfMA is gaining momentum in this heterogeneous ...
Shang Gao, Ruoyu Jin, Weisheng Lu
openaire   +1 more source