Results 131 to 140 of about 527,701 (305)
Designing for technology-mediated collaboration
, 2018 This thesis concerns the design of a synchronous shared workspace supporting technology-mediated collaboration. In order to collaborate, participants need to be able to coordinate the activity. And to coordinate an activity, they need be aware of others involved in the collaboration. However, what do we need to be aware of concerning the others?
openaire
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Frontiers in NutritionBackgroundThe relationship between vitamin D levels, depressive symptoms, and cognitive function has yet to be definitively understood in the elderly, particularly when considering the impact of chronic diseases.
Chang Shu +3 more
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
International Studies JournalThe increase in banditry and kidnapping in Nigeria has created significant security challenges in recent years, particularly with attacks on educational institutions where students are abducted for ransom.
SOLOMON AYANTAYO OJO +1 more
doaj
Frontiers in PsychologyAgainst the background that design students generally rely on artificial intelligence-generated design (AIGD) to address academic challenges, concerns have arisen about the potential dependency risks posed by its improper use.
Dan Wang, Zhenliang Wang
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Cogent EducationUnderpinned by constructivist learning theory (Feuerstein’s theory of mediated learning experience) and the cloud computing model, an experiment was conducted to examine the differences between the control and experimental groups regarding the linear ...
Sisay Ayalew Tsegaw +2 more
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Towards intelligent web services: the web service modeling ontology (WSMO) [PDF]
, 2005 The Semantic Web and the Semantic Web Services build a natural application area for Intelligent Agents, namely querying and reasoning about structured knowledge and semantic descriptions of services and their interfaces on the Web. This paper provides an
Domingue, John +5 more
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