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Tutorial on Causal Mediation Analysis for Pharmacometricians [PDF]

CPT: Pharmacometrics & Systems Pharmacology
Mediation analyses can support biomarker development by quantifying the part of the total treatment effect on clinical outcome that is mediated by the biomarker.
Sebastiaan Camiel Goulooze, Eleonora Marostica, Nelleke Snelder   +2 more
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Introduction to Mediation Analysis and Examples of Its Application to Real-world Data [PDF]

Journal of Preventive Medicine and Public Health, 2021
Traditional epidemiological assessments, which mainly focused on evaluating the statistical association between two major components-the exposure and outcome-have recently evolved to ascertain the in-between process, which can explain the underlying ...
Sun Jae Jung
doaj   +1 more source

A Practical Guide to Causal Mediation Analysis: Illustration With a Comprehensive College Transition Program and Nonprogram Peer and Faculty Interactions

Frontiers in Education, 2022
Experimental and quasi-experimental designs have been increasingly employed in education. Mediation analysis has long been used to measure the role of mediators.
W. Edward Chi, Sijia Huang, Minjeong Jeon, Elizabeth S. Park, Tatiana Melguizo, Adrianna Kezar   +5 more
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Role of covariates in the analysis of causal mediation effects

Sichuan jingshen weisheng, 2022
The purpose of this paper was to introduce the theoretical basis of the causal mediation effect analysis and the specific method to realize an example by the causal mediation effect analysis with SAS.
Hu Chunyan, Hu Liangping
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Mediation analysis methods used in observational research: a scoping review and recommendations

BMC Medical Research Methodology, 2021
Background Mediation analysis methodology underwent many advancements throughout the years, with the most recent and important advancement being the development of causal mediation analysis based on the counterfactual framework.
Judith J. M. Rijnhart, Sophia J. Lamp, Matthew J. Valente, David P. MacKinnon, Jos W. R. Twisk, Martijn W. Heymans   +5 more
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Sensitivity Analysis in Nonrandomized Longitudinal Mediation Analysis

Frontiers in Psychology, 2021
Mediation analysis relies on an untestable assumption of the no omitted confounders, which posits that an omitted variable that confounds the relationships between the antecedent, mediator, and outcome variables cannot exist.
Davood Tofighi
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Priming congruence and COVID-19 vaccination intention: a mediation analysis

Health Psychology Report, 2023
Background This study took place at the height of the fifth wave of COVID-19 in France, coinciding with stigmatizing communication toward the unvaccinated.
Lubomir Lamy, Jacques Fischer-Lokou, Nicolas Guéguen, Jérôme Guegan   +3 more
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Statistical methods for mediation analysis in the era of high-throughput genomics: Current successes and future challenges

Computational and Structural Biotechnology Journal, 2021
Mediation analysis investigates the intermediate mechanism through which an exposure exerts its influence on the outcome of interest. Mediation analysis is becoming increasingly popular in high-throughput genomics studies where a common goal is to ...
Ping Zeng, Zhonghe Shao, Xiang Zhou
doaj   +1 more source

Instrumental variable-based high-dimensional mediation analysis with unmeasured confounders for survival data in the observational epigenetic study

Frontiers in Genetics, 2023
Background: High dimensional mediation analysis is frequently conducted to explore the role of epigenetic modifiers between exposure and health outcome.
Fangyao Chen, Fangyao Chen, Weiwei Hu, Jiaxin Cai, Shiyu Chen, Aima Si, Yuxiang Zhang, Wei Liu   +7 more
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Key technology and multi-directional decomposition method of the causal mediation effect analysis

Sichuan jingshen weisheng, 2022
The purpose of this paper was to introduce five key techniques and the multi-directional decomposition methods of effect components in the analysis of causal mediation effects.
Hu Chunyan, Hu Liangping
doaj   +1 more source