Results 91 to 100 of about 13,832,790 (340)
Shifting towards non-anthropocentrism: in dialogue with speculative design futures
Futures, 2022 T. Hupkes, A. Hedman
semanticscholar +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Futures thinking becomes a priority for all globalized societies
Discover Global SocietyThis essay provides a concise impression of the many contemporary attempts to revitalize futures thinking. Futures thinking—in the sense of a systematic anticipatory approach based on sound scientific expertise and backed by socio-philosophical reasoning
Roland Benedikter
doaj +1 more source
UPC++ v1.0 Specification, Revision 2020.3.0 [PDF]
, 2020 UPC++ is a C++11 library providing classes and functions that support Partitioned Global Address Space (PGAS) programming. The key communication facilities in UPC++ are one-sided Remote Memory Access (RMA) and Remote Procedure Call (RPC).
Bachan, J, Bonachea, Dan, Kamil, A
core
Resilient ecological solutions for urban regeneration [PDF]
, 2012 There is a need for biological conservation at the global scale, and urban conservation has the potential to support the delivery of this wider goal.
Hale, James, Sadler, Jon
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Styling the Future. A philosophical account of scenarios & design [PDF]
, 2015 Since the end of the 1980s – the Decade of Style (Mort, 1996) – the value of style in design has fallen. Recent times (Whicher et al., 2015) see a focus on style as a sign of design’s immaturity, while a more mature design should be attending to process,
Brassett, Jamie, O'Reilly, John
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Prototypes as Future Artifacts of Today
On_CultureThe design of sociotechnical futures relies on institutionalized visions but also on material artifacts. In this context, prototypes are a materialized means of exploration of potential futures. This article explores interdependencies between irritations
Nils Matzner +3 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source