Results 101 to 110 of about 9,441,742 (293)

Prototypes as Future Artifacts of Today

On_Culture
The design of sociotechnical futures relies on institutionalized visions but also on material artifacts. In this context, prototypes are a materialized means of exploration of potential futures. This article explores interdependencies between irritations
Nils Matzner, Marcel Thiel-Woznica, Jordi Tost , Kevin Weller   +3 more
doaj   +1 more source

Teasing Paradoxes to Explore Transformative Futures of Peace [PDF]

This paper discusses the outcome of a methodologically innovative foresight exercise. A Futures Clinique was conducted to address paradoxes of peace. For the purpose, a novel method of p'aradox probing' was launched where paradoxes are employed as tools ...
Heinonen, Sirkka, Taylor, Amos, Pättikangas, Paula, Viitamäki, Riku   +3 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Enabling urban futures making through early-stage and punctuated design prototyping: the case of T-Factor local innovation hubs

Frontiers in Sustainable Cities
Futures thinking is a crucial skill for organisations navigating volatile, uncertain, complex, and ambiguous environments. Nonetheless, some researchers and practitioners argue that the insights futures thinking can yield appear obvious, trivial, or ...
Maria Vitaller del Olmo, Luca Simeone, Beatrice D’Ippolito, Amalia de Götzen, Nicola Morelli   +4 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

More-than-Human Food Futures Cookbook at Helsinki Design Week

, 2022
| openaire: EC/H2020/870759/EU//CreaTuresThe seven CreaTures experimental productions featured at the Helsinki Design Week 2022 exhibition. Experimental Food Design for Sustainable Futures was a two day workshop experimenting with food as bio-design ...
Wilde, Danielle, Davis, Hilary, van Gaalen, Sjef, Altarriba Bertran, Ferran, Dolejšová, Markéta   +4 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source