Results 121 to 130 of about 393,021 (297)
Design interventions, prediction and science in the sustainable transition of large, complex systems, [PDF]
, 2010 The way that human beings live and consume the natural and environmental resources of the planet are not sustainable. Sustainability involves changes in individual beliefs, expectations, values and behaviours at the microlevel, changes in policy at the ...
Dewberry, Emma, Johnson, Jeffrey
core
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
, 2020 Il futuro del design è strettamente legato alla visione più generale del creativo a prescindere dalla Disciplina di riferimento. Ciò che fa scattare una visione di futuro, parola il cui significato negli ultimi anni ha perso la sua portata creativa, non può che essere il dubbio inteso come antidoto all’ebrezza egocentrica di chi crea.
openaire +4 more sources
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Quality Improvement for Well Child Care [PDF]
, 2016 Presented to the Faculty of University of Alaska Anchorage in Partial Fulfillment of Requirements for the Degree of MASTER OF SCIENCEThe American Academy of Pediatrics (AAP) Bright Futures (BF) guidelines for well child care were designed to provide
Davis, Jessica L.
core
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
European Journal of Futures ResearchCircular futures research has extensively mapped competing imaginaries, but often leaves the institutional conditions for plausibility and scaling insufficiently specified. This article shows how institutional diversity shapes circular futures.
Brais Suárez-Eiroa +2 more
doaj +1 more source
Guest editorial: Developing learner agency in smart environments
Educational Technology & SocietySmart environments integrated with digital technologies have emerged as a powerful tool to support personalized, interactive, and adaptive learning experiences.
Sheng-Shiang Tseng, Yun Zhou
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source