Results 131 to 140 of about 9,441,742 (293)
Global Water Futures Briefing Book 2024 [PDF]
Second edition of GWF program briefing book, including updates from project annual reports submitted in 2023.Canada First Research Excellence FundNon-Peer ReviewedIn 2016, with initial funding through the Canada First Research Excellence Fund, the Global
Global Water Futures
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Futures spreads: theory and praxis [PDF]
Many professional traders, hedgers, and institutional investors utilise spread trading to engage in the futures market. Most of the literature dedicated to futures spreads was published between the late 1970s and early 1990s, and has partly lost its ...
Perchanok, Kirill
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Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
European Journal of Futures ResearchCircular futures research has extensively mapped competing imaginaries, but often leaves the institutional conditions for plausibility and scaling insufficiently specified. This article shows how institutional diversity shapes circular futures.
Brais Suárez-Eiroa +2 more
doaj +1 more source
Cognitive Redirective Mapping: Designing Futures that Challenge Anthropocentrism
, 2015 Humanity is facing, at both global and local levels, unprecedented challenges as the future, a byproduct of modernity, hurtles towards us. These future challenges are complex and world changing and include, but are not limited to, climate change ...
Schultz, Tristan, Barnett, Rebecca
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Transitions to Multispecies Futures in the Design Classroom
Sustainability Transitions and Futures is a mandatory course of the Creative Sus-tainability master’s program in the Department of Design of Aalto University de-livered jointly by the co-authors.
Gaziulusoy, İdil, Berglund, Eeva
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source