Results 151 to 160 of about 10,948,845 (303)
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Global Water Futures Briefing Book 2024 [PDF]
Second edition of GWF program briefing book, including updates from project annual reports submitted in 2023.Canada First Research Excellence FundNon-Peer ReviewedIn 2016, with initial funding through the Canada First Research Excellence Fund, the Global
Global Water Futures
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Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Cognitive Redirective Mapping: Designing Futures that Challenge Anthropocentrism
, 2015 Humanity is facing, at both global and local levels, unprecedented challenges as the future, a byproduct of modernity, hurtles towards us. These future challenges are complex and world changing and include, but are not limited to, climate change ...
Schultz, Tristan, Barnett, Rebecca
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Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Discover to Deliver Pediatric Futures: Viewpoints of Future Medicine From a Pediatric Health Care System. [PDF]
J Med Internet ResSincock Watkins V +5 more
europepmc +1 more source
Design Futures : An Investigation into the Role of Futures Thinking in Design. [PDF]
, 2010 Designers consider the future as an intrinsic aspect of the design process yet, there has been limited academic investigation of the approaches designers employ to create next-next generation products and services. The central aim of this thesis is to investigate the role of futures thinking in design.
openaire
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source