Results 201 to 210 of about 13,832,790 (340)

Future scenarios for British biodiversity under climate and land-use change. [PDF]

Nat Commun
Cooke R, Burton VJ, Brown C, Harrower CA, White SM, Huntingford C, Dunford-Brown R, Fox R, Harrison PA, Hui C, Massimino D, Purvis A, Robinson EL, Rodger J, Isaac NJB, Bullock JM.   +15 more
europepmc   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Toward a multi-level, needs-based approach to cancer navigation: Considerations for service design. [PDF]

Support Care Cancer
Thamm C, Bender J, Agbejule OA, Ramsey I, Crawford-Williams F, Ee C, McComb K, Agrawal AK, Chan RJ.   +8 more
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

What renewable energy future should we strive for? Assessing renewable energy utopias through Sci-Fi and normative energy ethics. [PDF]

Energy Sustain Soc
van Uffelen N, Wuebben D, Frigo G, Meinhold R, Simone L.   +4 more
europepmc   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Decentralized Biobanking Pathway to Precision Medicine: Futures Study.

J Med Internet Res
Gross M, Dewan A, Sabharwal K, Linkous A, Eifler M, Sanchez W, Miller R, Macis M, Rubin JC.   +8 more
europepmc   +1 more source

Towards a forward-looking ethnobiology: envisioning and co-creating biocultural futures. [PDF]

J Ethnobiol Ethnomed
Fernández-Llamazares Á, Teixidor-Toneu I.   +1 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source