Results 71 to 80 of about 13,832,790 (340)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Non-pharmacological solutions to sleep and circadian rhythm disruption: voiced bedside experiences of hospice and end-of-life staff caregivers

BMC Palliative Care, 2018
Background Sleep disturbance is a significant issue, particularly for patients with advanced terminal illness. Currently, there are no practice-based recommended approaches for managing sleep and circadian disruptions in this population.
Rana Sagha Zadeh, Elizabeth Capezuti, Paul Eshelman, Nicole Woody, Jennifer Tiffany, Ana C. Krieger   +5 more
doaj   +1 more source

Social Sustainability: A design research approach to sustainable development [PDF]

, 2011
While issues such as clean production and energy efficiency are still central in sustainable development discourse, attention is increasingly on patterns of consumption at multiple levels in society.
Gregory, Judith, Mazé, Ramia, Redström, Johan   +2 more
core   +2 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Future Design

, 2020
Il futuro del design è strettamente legato alla visione più generale del creativo a prescindere dalla Disciplina di riferimento. Ciò che fa scattare una visione di futuro, parola il cui significato negli ultimi anni ha perso la sua portata creativa, non può che essere il dubbio inteso come antidoto all’ebrezza egocentrica di chi crea.
openaire   +4 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Work in progress: a novel method of creating an academic content repository [PDF]

, 2009
This paper outlines a project aimed at addressing the issue of the scalability of online academic support. This project is being run during the Autumn semester at the University of Southern Queensland (USQ) Toowoomba Australia, in conjunction with the ...
Ayers, Ron, Harris, Glenn, Kist, Alexander A., Phythian, Mark, Reushle, Shirley, Taylor, Jim   +5 more
core   +1 more source

Extending temporalities in design: designing pluriversal futures

Codesign
This article addresses the challenges of designing pluriversal futures in complex and contested sociopolitical contexts by extending the temporal scope of design to address future imaginaries.
Asnath Paula Kambunga, Rachel Charlotte Smith, Heike Winschiers-Theophilus   +2 more
semanticscholar   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

A review of university chatbots for student support: FAQs and beyond

Discover Education
Within the university sector, student recruitment and enrolment are key strategies as institutions strive to attract, retain and engage students. This strategy is underpinned by the provision of services, applications and technologies that facilitate ...
Kevin Peyton, Saritha Unnikrishnan, Brian Mulligan   +2 more
doaj   +1 more source