Results 121 to 130 of about 23,644,290 (315)
Tactical intent-driven autonomous air combat behavior generation method
Complex & Intelligent SystemsWith the rapid development and deep application of artificial intelligence, modern air combat is incrementally evolving towards intelligent combat. Although deep reinforcement learning algorithms have contributed to dramatic advances in in air combat ...
Xingyu Wang +5 more
doaj +1 more source
International Journal of Nursing Studies AdvancesAim: This study examines the association between racial climate and racial microaggressions on nurses’ moral distress and intent to leave the organization.
Kari A. Mastro +6 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
IGTG&R: An Intent Analysis-Guided Unit Test Generation and Refinement Framework
EntropyCode coverage-guided unit test generation (CGTG) and large language model-based test generation (LLMTG) are two principal approaches for the generation of unit tests. Each of these approaches has its inherent advantages and drawbacks.
Xiaojian Liu, Yangyang Zhang
doaj +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Intent-Driven Cooperative Control of UAV Swarms: An LLM-Based Approach
Applied SciencesThe coordination of multiple unmanned aerial vehicles traditionally relies on pre-defined control strategies and complex programming implementations, making adaptation to dynamic environments and tasks challenging. The purpose of this study is to explore
Zhaoxin Li +4 more
doaj +1 more source