Results 111 to 120 of about 10,110,846 (278)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Design intent tool: User guide [PDF]
, 2002 This database tool provides a structured approach to recording design decisions that impact a facility's design intent in areas such as energy efficiency.Owners and de signers alike can plan, monitor and verify that a facility's design intent is being ...
Stum, Karl +9 more
core +2 more sources
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
IGTG&R: An Intent Analysis-Guided Unit Test Generation and Refinement Framework
EntropyCode coverage-guided unit test generation (CGTG) and large language model-based test generation (LLMTG) are two principal approaches for the generation of unit tests. Each of these approaches has its inherent advantages and drawbacks.
Xiaojian Liu, Yangyang Zhang
doaj +1 more source
Interrogative Design: Enhanced Interrogation with Intent [PDF]
, 2016 This research project explored possible relationships between torture and design. It concludes that design can be seen as an aesthetic quality. Design is a product of ‘intent’ and function. It is action aimed at producing a desired outcome.
Catts, Alexander Peter
core
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Intent-Driven Cooperative Control of UAV Swarms: An LLM-Based Approach
Applied SciencesThe coordination of multiple unmanned aerial vehicles traditionally relies on pre-defined control strategies and complex programming implementations, making adaptation to dynamic environments and tasks challenging. The purpose of this study is to explore
Zhaoxin Li +4 more
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source