Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
A Design Archival Approach to Knowledge Production in Design Research and Practice [PDF]
, 2019 Bondarenko O. +6 more
core +1 more source
Knowledge creation and visualisation by using trade-off curves to enable set-based concurrent engineering [PDF]
, 2016 The increased international competition forces companies to sustain and improve market share through the production of a high quality product in a cost effective manner and in a shorter time.
Al-Ashaab, Ahmed +2 more
core
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
Design for the contact zone. Knowledge management software and the structures of indigenous knowledges [PDF]
, 2010 This article examines the design of digital indigenous knowledge archives. In a discussion of the distinction between indigenous knowledge and western science, a decentred perspective is developed, in which the relationship between different local ...
van der Velden, Maja
core
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
MiR‐513a promotes human erythroid differentiation by modulating c‐Jun
FEBS Open Bio, EarlyView.During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim +11 more
wiley +1 more source
Development and Validation of a Rubric for Diagnosing Students' Experimental Design Knowledge and Difficulties. [PDF]
CBE Life Sci Educ, 2014 Dasgupta AP, Anderson TR, Pelaez N.
europepmc +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Knowledge modeling for software design [PDF]
This paper develops a modeling framework for systems engineering that encompasses systems modeling, task modeling, and knowledge modeling, and allows knowledge engineering and software engineering to be seen as part of a unified developmental process ...
Gaines, Brian R., Shaw, Mildred L. G.
core +1 more source