Results 91 to 100 of about 3,339,955 (267)

Research on the intelligent generation of the spatial form of the island city historic district Based on parameterization: taking Macau Taipa Village as an example

Journal of Asian Architecture and Building Engineering
In this paper, Macau Taipa Village, a historical district in an island-type city, is the research focus, and a parametric design-based method for designing historical districts is proposed.
Yile Chen, Liang Zheng, Lina Yan
doaj   +1 more source

Mechanical Performance of Joints with Bearing Plates in Concrete-Filled Steel Tubular Arch-Supporting Column-Prestressed Steel Reinforced Concrete Beam Structures: Numerical Simulation and Design Methods

Buildings
Research on the configuration and mechanical performance of arch-column-tie beam joints, which combine features of arch-tie beam joints and tubular joints, remains limited, particularly for long-span structures subjected to heavy loads at high building ...
Chongyang Li, Xianggang Su, Zhiliang Zuo, Lehua Huang, Yuezhou Zhou   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Design Approach for Composite Pavement Structure Incorporating Reflective Crack Considerations

Applied Sciences
The current design methods employed for composite pavement structures predominantly rely on cement concrete slabs, which unfortunately lack established design standards and associated control indicators for determining the appropriate thickness of the ...
Naren Fang, Xuesen Wang, Huanyu Chang, Kang Yu   +3 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Development and performance evaluation of a soft-contact earth pressure transducer for geotechnical centrifuge modeling

Yantu gongcheng xuebao
The miniature earth pressure transducer is one of the key testing tools in geotechnical centrifuge modeling. Aiming at solving the classical problems such as arching effects, size effects and thickness-diameter ratio in the measurement of rigid ...
WANG Yongzhi 1, 2, YANG Yang 1, 2, XU Guangming 3, TANG Zhaoguang 1, 2, ZHANG Xuedong 4, SUN Rui 1, 2, ZHOU Yanguo 5
doaj   +1 more source

Interconnect design methods for memory design [PDF]

ASP-DAC 2004: Asia and South Pacific Design Automation Conference 2004 (IEEE Cat. No.04EX753), 2004
Chanseok Hwang, Massoud Pedram
openaire   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source