Results 101 to 110 of about 2,171,100 (317)
Journal of Innovation and EntrepreneurshipSustainable research and innovation activities are mainly executed in collaborative networks consisting of stakeholders from academia, the economy, politics, and the media-based public considering the knowledge of the natural environment of societies. AI-
Lutz Peschke +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Set-Based Design Method Reflecting the Different Designers’ Intentions [PDF]
, 2009 Organised by: Cranfield UniversityThe previous series of the study have proposed a preference set-based design (PSD) method that enables the flexible and robust design under various sources of uncertainties. In contrast to the traditional design method,
Ishikawa, H., Inoue, M.
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Extending the gaia methodology for the design and development of agent-based software systems [PDF]
, 2007 Over the past decade, agent-based computing has emerged as a new and popular paradigm for design, implementation and analysis of distributed information systems.
Huang, W., Jin, L., El-Darzi, E.
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Modeling the early stages of a user-centered process in architectural design through adaptation of the methodologies of New Product Design [PDF]
, 2009 In order to reach a degree of quality in architectural buildings that is likely to lead to user satisfaction, architectural design relies on integrating user-related information even before generation of building concepts.
BOUCHARD, Carole +2 more
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Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Supporting Knitwear Design Using Case-Based Reasoning [PDF]
, 2009 Organised by: Cranfield UniversityKnitwear design is a creative activity that is hard to automate using the computer. The production of the associated knitting pattern, however, is repetitive, time-consuming and error-prone, calling for automation. Our
Richards, P., Ekárt, A.
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