Results 91 to 100 of about 2,171,100 (317)
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
, 2008 This article is posted with permission of OCP Science imprint. Copyright @ 2008 Old City Publishing Group.The development life cycle of software and electronic products has been shortened by the growth of rapid prototyping techniques.
Aktas, E, Yücel, G
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An integrated design methodology for components produced by laser powder bed fusion (L-PBF) process
Virtual and Physical Prototyping, 2018 Laser powder bed fusion (L-PBF) is an additive manufacturing (AM) process that allows to build full dense metal complex part. However, despite the obvious benefits of L-PBF process, it is affected by specific technological drawbacks and it suffers from ...
Alessandro Salmi +3 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Product/Service-System Design and Beyond
, 2011 In this book, leading experts in design methodology, most of them active in the Design Society, reflect the great progress that has been made, but also identify the challenges of future development of the topic.The reason that this book has been compiled
Sakao, Tomohiko,
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Digital modelling methodology for effective cost assessment [PDF]
, 2014 Research advances in digital factory design has led to a number of simulation techniques and tools which have the capability to represent aspects of the lifecycle of manufacturing systems. Although this is the case, analysis of key performance indicators
Ceglarek, Darek +5 more
core +1 more source
Implementation of Rapid Prototyping Tools for Power Loss and Cost Minimization of DC-DC Converters
Energies, 2016 In this paper, power loss and cost models of power electronic converters based on converter ratings and datasheet information are presented. These models aid in creating rapid prototypes which facilitate the component selection process.
Amruta V. Kulkarni +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Structured Design Automation [PDF]
, 2009 Organised by: Cranfield UniversityThe next stage in product development process evolution should be the automation of labour intensive repetitive steps.
van der Elst, S. W. G. +2 more
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