Results 71 to 80 of about 2,171,100 (317)
A Methodology for Agent-Oriented Analysis and Design
, 1999 This paper presents a methodology for agent-oriented analysis and design. The methodology is general, in that it is applicable to a wide range of multi-agent systems, and comprehensive, in that it deals with both the macro-level (societal) and the micro ...
Kinny, D. +8 more
core +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Toward proactive eco-design based on engineer and eco-designer's software interface modeling [PDF]
, 2011 Lien vers la version éditeur: http://www.designsociety.org/publication/30585/toward_proactive_eco-design_based_on_engineer_and_eco-designers_software_interface_modelingIntegrating environmental concerns as well as other constrains (cost, quality, etc ...
RIO, Maud +2 more
core
Agile Development Methodology for Embedded Systems: A Platform-Based Design Approach
, 2007 This paper describes an agile development methodology which combines agile principles with organizational patterns and adapts them to build embedded real-time systems focusing on the system's constraints.
Cordeiro, Lucas +12 more
core +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
, 2010 This paper addresses the role of the designer as actor/agency working within and across flows of knowledge, perception and information for filtering, negotiating and mediating design decision making.
Shumack, Kaye (R8571)
core
Participatory Design Methodology in Design Competition Practice
, 2019 More and more companies are trying various external design resources to meet their innovation needs. For example, design competitions can bring many innovative design ideas to enterprises, but leading, managing, and assessing innovation from a design ...
Chao, Lung-Chieh, Lung-Chieh Chao
core +1 more source
Design Methodology for Soft Wearable Devices—The MOSAR Case
Applied Sciences, 2019 This paper proposes a methodology from the conception to the manufacture of soft wearable devices (SWD). This methodology seeks to unify medical, therapeutic and engineering guidelines for research, development and innovation.
Juana-Mariel Dávila-Vilchis +3 more
doaj +1 more source