Results 51 to 60 of about 2,171,100 (317)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The Topology of the Leg Joints of the Beetle Pachnoda marginata (Scarabaeidae, Cetoniinae) and Its Implication for the Tribological Properties

open access: yesBiomimetics, 2018
Locomotion of walking insects is exceptionally efficient. The function of their leg joints in different movement scenarios depends on their kinematics and contacting conditions between moving parts.
Steffen Vagts   +3 more
doaj   +1 more source

Effective Design Methodology of CLLC Resonant Converter Based on the Minimal Area Product of High-Frequency Transformer

open access: yesEnergies, 2023
In DC microgrids, CLLC topology is commonly applied for battery integration. It provides galvanic separation, the ability to integrate a high-frequency transformer into the resonance circuit, and the ability to operate in a wide range of voltage ...
Magdalena Bartecka   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Design methodology for wing trailing edge device mechanisms [PDF]

open access: yes, 2007
Over the last few decades the design of high lift devices has become a very important part of the total aircraft design process. Reviews of the design process are performed on a regular basis, with the intent to improve and optimize the design process.
Martins Pires, Rui Miguel
core  

TIFAIFAI : Conception de Nouveaux Espaces d’Interactions pour Apprendre

open access: yesDistances et Médiations des Savoirs, 2014
Contemporary education is more and more dependent upon computerized tools and technology delivery systems. These devices are often presented to teachers without specific modalities of educational activities or scenarios.
Valérie Renault   +2 more
doaj   +1 more source

Analysis and Design Methodology of Radial Flux Surface-Mounted Permanent Magnet Synchronous Motors

open access: yesEng, 2023
Permanent magnet motors have become very important in recent years due to the popularization of electric vehicles in the context of the efforts to transition to zero-emission transportation.
Sergio I. Suriano-Sánchez   +5 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

A Methodology for Variability Reduction in Manufacturing Cost Estimating in the Automotive Industry based on Design Features [PDF]

open access: yes, 2009
Organised by: Cranfield UniversitySmall to medium manufacturing companies are coming to realise the increasing importance of performing fast and accurate cost estimates at the early stages of projects to address customers’ requests for quotation ...
Romero Rojo, Francisco Javier   +2 more
core  

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