Results 251 to 260 of about 2,171,100 (317)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Open Design and Crowdsourcing: Maturity, Methodology and Business Models [PDF]

open access: yes, 2012
McAloone, Tim C.   +6 more
core  

Use of Human-Centered Design Methodology to Develop a Digital Toolkit to Optimize Heart Failure Guideline-Directed Medical Therapy. [PDF]

open access: yesJ Cardiovasc Nurs
Spaulding EM   +20 more
europepmc   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian   +8 more
wiley   +1 more source

Generations in design methodology

open access: yesProceedings of DRS, 2002
The relationship between design and science is examined through the lens of design methodology. The purpose is to foresee the next generation of design methodology and its attributes.
Broadbent, J.
openaire   +2 more sources
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Methodology for LAN design

Computer Communications, 1986
Abstract A methodology is presented which allows the description of the relationships between user requirements and a LAN that will satisfy them. This methodology has been developed using the SADT technique, which has been shown to be an effective tool to describe the design phases and their functional relationships within complex and heterogeneous ...
CHIANESE, ANGELO, DE SANTO M.
openaire   +2 more sources

Design Methodology for ΣΔM

IEEE Transactions on Communications, 1983
The paper presents a design methodology based on correspondence between performance requirements, mathematical parameters, and circuit parameters of a sigma-delta modulator. This methodology will guide a design engineer in selecting the circuit parameters based on system requirements, in translating paper design directly into LSI design, in predicting ...
Bhagwati Prasad Agrawal, Kishan Shenoi
openaire   +1 more source

Evaluation of design methodologies

ACM SIGSOFT Software Engineering Notes, 1982
This proposal seeks to evaluate the effects of various design methodologies on the development and maintenance of computer systems. More specifically, an experiment is proposed to test the hypothesis that the cost of making changes to computer systems is influenced by the application area of the system and by the design methodology employed in its ...
Makoto Arisawa   +9 more
openaire   +1 more source

A "design for verification" methodology

Proceedings of the IEEE 2001. 2nd International Symposium on Quality Electronic Design, 2002
New tools are becoming available on the market that help alleviate the problem and improve the quality of functional verification of today's complex systems. A methodology that makes use of such tools is described and compared to the traditional approach followed in the context of a specific project.
F. Sforza   +4 more
openaire   +1 more source

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