Results 221 to 230 of about 3,979,734 (303)

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Synergistic Influence of Multi-Walled Carbon Nanotubes and Nanosilica Powder on Mechanical Performance of Mortar with Demolished Concrete Waste Aggregate and Polypropylene Fibers Addition Using Taguchi Design of Experiment. [PDF]

Materials (Basel)
Lepadatu D, Judele LE, Bucur DR, Simion IM, Entuc IS, Proaspat E, Teodorescu RI, Kobi A, Garcia-Granda S.   +8 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Design and experiment of air-suction drum-type seedling seeder for irregular-shaped vegetable seeds. [PDF]

Sci Rep
Li Y, Liu Y, Ning Y, Wu H, Zhao Y.
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Eco-Friendly and Ready-To-Market Polyurethanes: A Design of Experiment-Guided Substitution of Toxic Catalyst and Fossil-Based Isocyanate. [PDF]

ChemSusChem
Viada G, Mariotti N, Galliano S, Menozzi A, Barolo C, Bonomo M.   +5 more
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Improving productivity of citramalate from CO₂ by Synechocystis sp. PCC 6803 through design of experiment. [PDF]

Biotechnol Biofuels Bioprod
Faulkner M, Andrews F, Scrutton N.
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

In silico analysis of design of experiment methods for metabolic pathway optimization. [PDF]

Comput Struct Biotechnol J
Moreno-Paz S, Schmitz J, Suarez-Diez M.
europepmc   +1 more source