Results 101 to 110 of about 4,547,694 (285)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Nonparametric time trends in optimal design of experiments. [PDF]
When performing an experiment, the observed responses are often influenced by a temporal trend due to aging of material, learning effects, equipment wear-out, warm-up effects, etc. The construction of run orders that are optimally balanced for time trend
Tack, Lieven, Vandebroek, Martina
core
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Automobile Workshop Queue System Optimization Using Response Surface [PDF]
International Journal of Industrial Engineering and Production ResearchThe automobile workshop queue system has been optimized using various approaches, such as queuing theory, simulation, and probability. The utilization of response surface methodology (RSM) for optimizing automobile workshop queue systems is not yet ...
Welly Sugianto +2 more
doaj
Using Remote Access for Sharing Experiences in a Machine Design Laboratory [PDF]
, 2013 A new Machine Design Laboratory at Marquette University has been created to foster student exploration and promote “hands-on” and “minds-on” learning. Laboratory experiments have been developed to give students practical experiences and expose them to ...
Marklin, Richard W., Jr. +2 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Improved Design of Queuing Simulation Experiments with Highly Heteroscedastic Responses [PDF]
queueing network;experimental ...
Cheng, R.C.H., Kleijnen, J.P.C.
core +3 more sources
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Preliminary design of two Space Shuttle fluid physics experiments [PDF]
The mid-deck lockers of the STS and the requirements for operating an experiment in this region are described. The design of the surface tension induced convection and the free surface phenomenon experiments use a two locker volume with an experiment ...
Gat, N., Kropp, J. L.
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source