Results 81 to 90 of about 4,547,694 (285)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Optimal Foldover Plans for Resolution IV Designs with 17 to 21 Factors
MathematicsThis paper provides an identification of optimal foldover plans for two-level fractional factorial designs involving 17 to 21 factors, thereby augmenting the repertoire of available optimal foldover plans for resolution IV designs.
Hazael Zarco-Murillo +5 more
doaj +1 more source
R Package DoE.base for Factorial Experiments
Journal of Statistical Software, 2018 The R package DoE.base can be used for creating full factorial designs and general factorial experiments based on orthogonal arrays. Besides design creation, some analysis functionality is also available, particularly (augmented) half-normal effects ...
Ulrike Grömping
doaj +1 more source
Statistical considerations in design of spacelab experiments [PDF]
After making an analysis of experimental error sources, statistical models were developed for the design and analysis of potential Space Shuttle experiments.
Robinson, J.
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Design and Analysis of Monte Carlo Experiments [PDF]
monte carlo experiments;simulation models;mathematical analysis;sensitivity analysis;experimental ...
Kleijnen, J.P.C.
core +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
On Metamodeling of Electronic Circuits using Efficient Experiment Plans [PDF]
Journal of Electrical and Electronics Engineering, 2020 The use of metamodels has become more and more frequent when it comes to the analysis and optimization of simulations, as they are capable of predicting the behavior of a system in a much shorter time compared to normal simulations, but with comparable ...
CĂRBUNESCU-STOENESCU Bianca-Raluca +4 more
doaj
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source