Results 81 to 90 of about 315,391 (267)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Interpretation of a General Model for Inventive Problems, the Generalized System of Contradictions [PDF]
, 2009 Organised by: Cranfield UniversityDesign of technical systems implies either optimisation or inventive problems resolution. Resolution tools and methods exist for each kind of problems.
Dubois, S., De Guio, R., Rasovska, I.
core
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Designing the Search Experience [PDF]
, 2011 This half-day tutorial provides a practical introduction to Human-Centred Design for information search, access and discovery. We present a concise overview of the fundamental concepts and principles of human information-seeking behaviour and show how to apply these in the design of search user experiences.
openaire +2 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Optimal Foldover Plans for Resolution IV Designs with 17 to 21 Factors
MathematicsThis paper provides an identification of optimal foldover plans for two-level fractional factorial designs involving 17 to 21 factors, thereby augmenting the repertoire of available optimal foldover plans for resolution IV designs.
Hazael Zarco-Murillo +5 more
doaj +1 more source
Design of experiments to investigate multi-additive cellulose nanocrystal films
, 2022 Cellulose nanocrystal (CNC) suspensions can self-assemble into chiral nematic films upon the slow evaporation of water. These films are brittle, as indicated by their fracturing instead of plastically deforming once they are fully elastically deformed ...
Vapaavuori, Jaana +5 more
core +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
R Package DoE.base for Factorial Experiments
Journal of Statistical Software, 2018 The R package DoE.base can be used for creating full factorial designs and general factorial experiments based on orthogonal arrays. Besides design creation, some analysis functionality is also available, particularly (augmented) half-normal effects ...
Ulrike Grömping
doaj +1 more source