Results 71 to 80 of about 4,547,694 (285)

Kernelized design of experiments [PDF]

This paper describes an approach for selecting instances in regression problems in the cases where observations x are readily available, but obtaining labels y is hard.
Rüping, Stefan, Weihs, Claus
core  

Design of Experiments for Screening

, 2015
The aim of this paper is to review methods of designing screening experiments, ranging from designs originally developed for physical experiments to those especially tailored to experiments on numerical models. The strengths and weaknesses of the various
A Boukouvalas, A Marrel, A Miller, A Saltelli, A Saltelli, A.E. Vine, AB Owen, AC Atkinson, AM Dean, B Abraham, B Bettonvil, B Bettonvil, B. Tang, B. Tang, BA Jones, BA Jones, BA Jones, C Daniel, C Linkletter, C.F.J. Wu, C.F.J. Wu, CA Mauro, CE Rasmussen, CJ Marley, CR Rao, CS Cheng, D Draguljić, D Dupuy, D Scott-Drechsel, D. Xing, D.T. Voss, DA Bulutoglu, DJ Finney, DKJ Lin, DKJ Lin, EI George, F Campolongo, F Campolongo, F Satterthwaite, FKH Phoa, FKH Phoa, G Damblin, G Pujol, G.S. Watson, GEP Box, GEP Box, GEP Box, GEP Box, GM James, H Moon, H. Wan, H. Xu, H. Yang, H.B.E. Wan, HA Chipman, JL Loeppky, JPC Kleijnen, K.Q. Ye, KHV Booth, KJ Ryan, KP Burnham, KT Fang, L Pronzato, L. Xiao, M Claeys-Bruno, M Hamada, M Hamada, M Johnson, M Liu, M.A. Wolters, MD McKay, MD Morris, MD Morris, MD Morris, MJ Hall, N Durrande, NA Butler, NK Nguyen, NK Nguyen, NK Nguyen, PR Scinto, PZG Qian, PZG Qian, PZG Qian, R Dorfman, R Jin, R Joseph, RB Gramacy, RK Meyer, RL Iman, RL Plackett, RV Lenth, S Ba, SC Cotter, SG Gilmour, SM Lewis, TJ Santner, VE Bowman, W DuMouchel, W Li, W.J. Welch, WA Brenneman, WW Li, X Qu, Y Benjamini, Y Liu   +105 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Design of experiments for microbiological models [PDF]

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Dette, Holger, Melas, Viatcheslav B., Strigul, Nikolay   +2 more
core  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Exemplary Design Research [PDF]

, 2006
In this paper, we will look at what role a research program and an interventionist research strategy based on design experiments may play for the advancement of knowledge relevant to design and designers.
Binder, Thomas, Redström, Johan
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

On the Design of Peer Punishment Experiments [PDF]

We discuss how technologies of peer punishment might bias the results that are observed in experiments. A crucial parameter is the “fine-to-fee” ratio, which describes by how much the punished subjects income is reduced relatively to the fee the ...
Marco Casari
core  

Computer program simulates design, test, and analysis phases of sensitivity experiments [PDF]

, 1967
Modular program with a small main program and several specialized subroutines provides a general purpose computer program to simulate the design, test and analysis phases of sensitivity experiments.
Alexander, M. J., Rothman, D., Zimmerman, J. M.   +2 more
core   +1 more source