Results 71 to 80 of about 168,505,770 (297)
PharmaceuticsNDH-4338 is a highly lipophilic prodrug comprising indomethacin and an acetylcholinesterase inhibitor. A design of experiments approach was used to synthesize, characterize, and evaluate the wound healing efficacy of optimized NDH-4338 nanosuspensions ...
Tomas L. Roldan +7 more
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Analysis of Quenching Parameters in AISI 4340 Steel by Using Design of Experiments [PDF]
Materials Research, 2018 This paper aims to investigate the effects of quenching parameters (temperature and time of austenitizing and cooling rate) on the microstructure, hardness and distortion of AISI 4340 steel by Design of Experiments (DoE). The factorial design was used to
Marlon Muniz Nunes +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
A Comparison of Ballistic Resistance Testing Techniques in the Department of Defense
IEEE Access, 2014 Ballistic resistance testing is conducted in the Department of Defense (DoD) to estimate the probability that a projectile will perforate the armor of a system under test.
Thomas H. Johnson +3 more
doaj +1 more source
Development of Geopolymers for Catalyst Support Applications [PDF]
Materials Research, 2019 A geopolymer with high specific surface area was synthesized from metakaolin, amorphous silica and KOH, in the absence of foaming or saponification agents. The mixture modelling technique was selected for this study among the Design of Experiments tools,
Leo Vieira +4 more
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
A Comparative Study of Alkaline Hydrolysis of Ethyl Acetate Using Design of Experiments [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2013 Alkaline hydrolysis of ethyl acetate is essentially an irreversible and second order reaction. Industrial importance of the reaction product, sodium acetate, necessitate for process improvement in terms of maximum conversion and economical usage of raw ...
Afzal Ahmad +4 more
doaj
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Workshop: Experimenting with design experiments
, 2013 This (proposal for a) full day workshop intends to explore design experiments to create a deeper understanding of the underpinning mindsets, epistemological assumptions and their implications as well as possibilities within the context of academic ...
Westerlund, Bo, +3 more
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