Results 51 to 60 of about 4,547,694 (285)
Systematic optimization of human pluripotent stem cells media using Design of Experiments. [PDF]
, 2015 Human pluripotent stem cells (hPSC) are used to study the early stages of human development in vitro and, increasingly due to somatic cell reprogramming, cellular and molecular mechanisms of disease.
Chailangkarn, Thanathom +2 more
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
A calculation model for liquid-liquid extraction of protactinium by 2,6-dimethyl-4-heptanol
Nukleonika, 2015 Reprocessing of spent nuclear fuel usually employs the solvent extraction technique to recover fissile material, isolate other valuable radionuclides, recover precious metals, and remove contaminants.
Knight Andrew W. +3 more
doaj +1 more source
QbD Based Media Development for the Production of Fab Fragments in E. coli
Bioengineering, 2019 Ranibizumab is a biotherapeutic Fab fragment used for the treatment of age-related macular degeneration and macular oedema. It is currently expressed in the gram-negative bacterium, Escherichia coli.
Deepak Kumar +3 more
doaj +1 more source
R Package OBsMD for Follow-Up Designs in an Objective Bayesian Framework
Journal of Statistical Software, 2020 Fractional factorial experiments often produce ambiguous results due to confounding among the factors; as a consequence more than one model is consistent with the data. Thus, the practical problem is how to choose additional runs in order to discriminate
Laura Deldossi, Marta Nai Ruscone
doaj +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Interaction Design: Foundations, Experiments [PDF]
, 2006 Interaction Design: Foundations, Experiments is the result of a series of projects, experiments and curricula aimed at investigating the foundations of interaction design in particular and design research in general.
Hallnäs, Lars, Redström, Johan
core +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Design of Calibration Experiments for Identification of Manipulator Elastostatic Parameters [PDF]
, 2012 The paper is devoted to the elastostatic calibration of industrial robots, which is used for precise machining of large-dimensional parts made of composite materials.
Caro, Stéphane +4 more
core +3 more sources
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source