Results 61 to 70 of about 315,391 (267)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Nested row-column designs for near-factorial experiments with two treatment factors and one control treatment

, 2015
The authors also thank Queen Mary, University of London, the University of St Andrews and the Poznan University of Life Sciences for financial support. The second author was also supported by the British-Polish Young Scientists Programme, grant WAR/342 ...
Bailey, Rosemary Anne, A. Lacka, Lacka, Agnieszka, R. A. Bailey   +3 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Electrical Aging of the Insulation of Low Voltage Machines: Model definition and test with the Design of Experiments [PDF]

, 2013
The aim of this paper is to present a method for modeling the lifespan of insulation materials in a partial discharge regime. Based on the design of experiments, it has many advantages: it reduces the number of time-consuming experiments, increases the ...
Nadine Lahoud, David Malec, Malec, David, Maussion, Pascal, Lahoud, Nadine, Pascal Maussion, Jerome Faucher, Faucher, Jérôme   +7 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Optimizing Nanosuspension Drug Release and Wound Healing Using a Design of Experiments Approach: Improving the Drug Delivery Potential of NDH-4338 for Treating Chemical Burns

Pharmaceutics
NDH-4338 is a highly lipophilic prodrug comprising indomethacin and an acetylcholinesterase inhibitor. A design of experiments approach was used to synthesize, characterize, and evaluate the wound healing efficacy of optimized NDH-4338 nanosuspensions ...
Tomas L. Roldan, Shike Li, Christophe Guillon, Ned D. Heindel, Jeffrey D. Laskin, In Heon Lee, Dayuan Gao, Patrick J. Sinko   +7 more
doaj   +1 more source

A Comparison of Ballistic Resistance Testing Techniques in the Department of Defense

IEEE Access, 2014
Ballistic resistance testing is conducted in the Department of Defense (DoD) to estimate the probability that a projectile will perforate the armor of a system under test.
Thomas H. Johnson, Laura Freeman, Janice Hester, Jonathan L. Bell   +3 more
doaj   +1 more source

Design and Implementation of a Bespoke Robotic Manipulator for Extra-corporeal Ultrasound [PDF]

, 2019
With the potential for high precision, dexterity, and repeatability, a self-tracked robotic system can be employed to assist the acquisition of real-time ultrasound.
Singh, Anisha, Lindenroth, Lukas, Back, J, Noh, Yohan, Hajnal, J, Althoefer, K, Hajnal, Joseph; id_orcid, Lindenroth, L, Liu, H, Singh, A, Housden, James, Wang, Shuangyi; id_orcid, Singh, D, Back, Junghwan, Liu, Hongbin, Noh, Y, Althoefer, Kaspar, Singh, Davinder, Wang, S, Rhode, Kawal; id_orcid, Housden, J, Rhode, K   +21 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source